The Id product line includes Rabbit Monoclonals against Id1, Id2, Id3, and Id4. Research has shown that these Rabbit anti-Id monoclonals are the best commercially available Id antibodies and the only anti-Id1, Id2, Id3, and Id4 antibodies that work in immunohistochemistry with formalin fixed, paraffin embedded tissues.
Human Breast tumor stained with Rabbit Monoclonal anti-Human/Mouse Id1 Clone 195-14. Specific Id1 staining can be seen in the nucleus of endothelial cells. (courtesy of Dr. Robert Benezra, Sloan Kettering Cancer Institute)
There are four members of the Id protein family, Id1, Id2, Id3 and Id4. These proteins were initially discovered as proteins involved in the negative control of cell differentiation. Id proteins act as a negative regulator of transcription through physical interaction with a group of transcription factors known as bHLH (basic helix-loop-helix) proteins. Because of this activity, the group of proteins were named as Id Proteins (for inhibitor of DNA binding). Id proteins may play a central role in coordinating gene expression, cell proliferation, tumorigenesis, and angiogenesis. For more detailed information, download an Id products brochure here.
We have ten different clones available for Human and Mouse Id1, Id2, Id3, and Id4. For specific data sheets on each clone, please click on the link for each catalog number in the table below.